Skip to main content
Join the Patient Engagement Forum.Share your experiences by joining our Patient Engagement Forum.

PGT-M conditions

The page below lists all PGT-M conditions currently authorised and awaiting consideration by the HFEA.

When publishing genetic conditions on the authorised list, we aim to be as consistent as possible with the OMIM database. However, many conditions may have several different names and we would recommend searching the list using the OMIM number for the condition as this is less likely to change throughout time.

If a condition does not appear on the list, it does not necessarily mean the condition has specifically not been authorised, it may mean that we have never before received an application from a UK centre to perform PGT-M for this condition and it has therefore never been considered by the HFEA.

Please note that we are always processing new applications to add genetic conditions to the list from UK centres licensed to perform PGT-M. This may mean that some authorised conditions may not be displayed. If you are unsure if a condition has been authorised or not, or would like any further information please contact the PGTM team at pgtm@hfea.gov.uk.

Click here for a downloadable list: approved condition list. Please note that the website page below is updated more regularly and is therefore more accurate than the downloadable list.

Condition name Status OMIM number Documents
Mitochondrial DNA Depletion Syndrome 9 (MTDPS9) approved 245400
Mitochondrial Myopathy and Ataxia (MMYAT) approved 617675 (autosomal recessive)
Mitochondrial short-chain enoyl-CoA hydratase 1 deficiency (ECHS1D; Leigh syndrome) approved 616277
Mitochondrial Trifunctional Protein Deficiency approved 609015
Molybdenum Cofactor Deficiency Type B (MOCODB) approved 252160
Muckle-Wells Syndrome (MWS) approved 191900
Mucolipidosis III Alpha/Beta approved 252600
Mucolipidosis III Gamma approved 252605
Mucolipidosis IV (ML4) approved 252650
Mucolipidosis type II approved 252500
Mucopolysaccharidosis III (MPS-III) Type A (Sanfilippo syndrome A) approved 252900
Mucopolysaccharidosis III (MPS-III) Type B approved 252920
Mucopolysaccharidosis III (MPS-III) Type C approved 252930
Mucopolysaccharidosis III (MPS-III) Type D approved 252940
Mucopolysaccharidosis IVA approved 253000
Mucopolysaccharidosis Type I (MPS I) approved 607014, 607015, 607016
Mucopolysaccharidosis Type II (Hunter Syndrome) approved 309900
Mucopolysaccharidosis Type IVB (MPS4B) approved 253010
Mucopolysaccharidosis Type VI (MPS VI) (Maroteaux-Lamy Syndrome) approved 253200
Mucopolysaccharidosis Type VII (MPS7) approved 253220