Split-Hand/Foot Malformation 4 (SHFM4)

Split-Hand/Foot Malformation 4 (SHFM4)

OMIM number: 605289

Comments closing date: 28/11/2024

Split hand/foot malformation (SHFM) is a limb
abnormality that is present at birth. It is
characterized by absence of certain fingers and
toes (ectrodactyly) that suggest a claw-like
appearance and webbing of fingers and toes may
also be present. This results in lifelong, physical
disability for the affected patients. There is
variability in the severity of symptoms between
patients; Severity can vary even among members
of the same family.

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